At the core of Synbio’s offerings is its expertise in both Chinese Hamster Ovary (CHO) and Human Embryonic Kidney 293 (HEK293) cell systems. These two widely used platforms each have distinct advantages, enabling Synbio to offer flexible solutions that meet diverse research and production requirements. CHO cells are renowned for their ability to produce high yields of post-translationally modified proteins, making them ideal for the production of biologics and therapeutic proteins. On the other hand, HEK293 cells are favored for their rapid growth rates and ease of transfection, which allows for quick turnaround times in experimental setups.
Choosing Between HEK293 and CHO Cells
When selecting the right mammalian expression system, the choice between HEK293 cells and CHO cells can significantly impact the outcome of protein production. HEK293 cells are known for their high transfection efficiency and rapid growth. These human cell lines facilitate transient expression, making them ideal for quick experiments and shorter timelines. For companies prioritizing speed and efficiency in initial trials, Synbio recommends utilizing HEK293-based mammalian expression plasmids.
On the other hand, CHO cells provide unique advantages in scalability and post-translational modifications. While they exhibit slower growth rates compared to HEK293 cells, CHO cells allow for both transient and stable expression, making them an excellent choice for large-scale production where consistent quality and yield are critical. Synbio’s expertise in CHO systems ensures that clients can maximize the potential of their mammalian expression plasmids while achieving the desired biological characteristics of their target proteins.
Conclusion
Businesses are increasingly looking for expertise in choosing and implementing the most efficient mammalian expression systems as the need for high-quality protein production rises due to developments in medicinal discovery, vaccine production, and recombinant protein applications. In this complicated environment, Synbio stands out as an informed partner that offers crucial advice and insights to assist clients in making wise decisions.
